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*NEW FUNDING ALERT*
September 2025: Excited to share that our lab has been awarded a new NIH R01 grant to investigate how lysosomal ion channels shape cardiomyocyte survival and resilience in ischemic heart disease. This project will focus on the calcium/proton-permeable channel TPC2, which we’ve found to be markedly upregulated after cardiac injury and linked to progressive heart failure. By uncovering how TPC2-driven ion release promotes cell death and maladaptive remodeling, we aim to identify new therapeutic strategies to protect the heart after myocardial infarction.
March 2025: Undergraduate student, Ali Hamed, was granted a prestigious Diamond Research Scholars award to carry out an independent research project over the next year. His work aims to define a novel lysosome-based cAMP/PKA nanodomain that governs ion channel activity and inter-organelle crosstalk. Congrats Ali!
March 2024: Undergraduate student, Namratha Javvaji, was granted a prestigious Diamond Research Scholars award to carry out an independent research project over the next year. Her work is aimed at studying the causal relationship between lysosomal pH dynamics and organellar function in the context of ischemic heart disease. Congrats Namratha!
*NEW FUNDING ALERT*
December 2023: Thrilled to announce a major funding boost from the W.W. Smith Charitable Trust, which is helping us uncover why oxidized PKA's cardioprotective effects are lost in chronic ischemic heart disease and what we can do, therapeutically, to restore them.